个人简介

施蕴渝 中国科学院院士、发展中国家科学院院士、博士生导师、中国科学技术大学生命科学学院教授。1965年毕业于中国科学技术大学物理系生物物理专业。1965年-1970年卫生部中医研究院实习研究员。1970年-至今年中国科学技术大学助教，讲师，副教授，教授。合肥微尺度物质科学国家实验室（筹）研究员。1979年-1981年意大利罗马大学化学系，CNRS结构化学实验室进修。曾作为访问学者在荷兰格罗宁根大学物理化学系，法国CNRS酶学与结构生物学实验室，法国理论化学实验室进修或合作研究。

学术任职:

Council Member of International Society of Magnetic Resonance (ISMAR)；

Current Opinion in Structural Biology，Editorial Board member；

Biochemistry, Editorial Advisory Board member；

Faculty F1000，Editorial Advisory Board member;

Science in China，Life Sciences，Editorial Board member；

中国生物物理学会常务理事；

北京中科院生物物理所生物大分子国家重点实验室学术委员会主任

研究兴趣:

我们实验室对基因表达过程中表观遗传调控，特别是组蛋白修饰，染色体重塑，组蛋白分子伴侣及非编码RNA的调节感兴趣。我们也对非编码RNA与蛋白质的相互作用感兴趣。我们用结构生物学的方法（核磁共振波谱，晶体衍射）及其它生物物理，生物化学方法研究基因表达调控的分子机理的结构生物学基础相关研究成果先后在Proc. Natl. Acad. Sci. USA, Genes & Development, Cell Signaling, Nucleic Acids Res., J. Biolo. Chem.等国际重要学术期刊发表文章120余篇。文章被引用2000多次。

近年发表论文 (*:责任作者)

1) Wang W, Wang L, Zou Y, Zhang J, Gong Q, Wu J, Shi Y*. Cooperation of Escherichia coli Hfq hexamers in DsrA binding. Genes and Development 2011; 25(19):2106-17.

2) Qiu Y, Liu L, Zhao C, Han C, Li F, Zhang J, Wang Y, Li G, Mei Y, Wu M, Wu J*, Shi Y*. Combinatorial Readout of Unmodified H3R2 and Acetylated H3K14 by the Tandem PHD Finger of MOZ Reveals a Regulatory Mechanism for HOXA9 Transcription. Genes and Development. 2012, 26(12):1376-91.

3) He C., Pillai S. S., Taglini F., Li F., Ruan K., Zhang J., Wu J., Shi* Y., and Bayne* E. H., A novel tandem zinc finger domain in Stc1: structural insights into the coupling of RNAi and chromatin modification, Proc Natl Acad Sci U S A , 2013 May 21;110(21):E1879-88

4) Li S, Wandel MP, Li F, Liu Z, He C, Wu J, Shi* Y, Randow F*. Sterical Hindrance Promotes Selectivity of the Autophagy Cargo Receptor NDP52 for the Danger Receptor Galectin-8 in Antibacterial Autophagy. Sci. Signal. 2013 Feb 5;6(261):ra9. doi: 10.1126/scisignal.2003730.（被F1000推荐）

5) He C., Li F., Zhang J., Wu J*., Shi Y*., The methyltransferase NSD3 has chromatin-binding motifs, PHD5-C5HCH, that are distinct from other NSD family members in their histone H3 recognition, J. Biol. Chem., 2013, 288(7):4692-703.

6）Wang L, Wang W, Li F, Zhang J, Wu J, Gong Q*, Shi Y*. Structural insights into the recognition of the internal A-rich linker from OxyS sRNA by Escherichia coli Hfq. Nucleic Acids Res. 2015, 43(4):2400-11.

7）Liu Z, Li F, Zhang B, Li S, Wu J*, Shi Y*. Structural Basis of Plant Homeodomain Finger 6 (PHF6) Recognition by Retinoblastoma Binding Protein 4 (RBBP4) Component of the Nucleosome Remodeling and Deacetylase (NuRD) Complex. J Biol Chem. 2015，290(10)，6630-8

8) Li F, Zhao D, Wu J*, Shi Y*. Structure of the YTH domain of human YTHDF2 in complex with an m(6)A mononucleotide reveals an aromatic cage for m(6)A recognition. , Cell Res. 2014 Dec;24(12):1490-2.

9）Wang C, Zhu Y, Caceres TB, Liu L, Peng J, Wang J, Chen J, Chen X, Zhang Z, Zuo X, Gong Q, Teng M, Hevel JM, Wu J*, Shi Y*. Structural Determinants for the Strict Monomethylation Activity by Trypanosoma brucei Protein Arginine Methyltransferase 7 , Structure. 2014, 22(5):756-68.

10）Wang J, Qin S, Li F, Li S, Zhang W, Peng J, Zhang Z, Gong Q, Wu J*, Shi Y*. Crystal structure of human BS69 Bromo-ZnF-PWWP reveals its role in H3K36me3 nucleosomes binding. Cell Res. 2014.24, 890-3 2014.38.

11）Liu Z, Li F, Ruan K, Zhang J, Mei Y, Wu J*, Shi Y*, Structural and functional insights into the human Börjeson-Forssman-Lehmann syndrome-associated protein PHF6.J Biol Chem. 2014, 289(14):10069-83

12) Wang L., Wang W, Li F., Zhang J, Wu J., Gong*Q. and Shi*Y. ,Structural insights into the recognition of the internal A-rich linker from OxyS sRNA by Escherichia coli Hfq. Nucleic Acids Research (2015) 43(4):2400-2411.

13) Liu Z., Li F., Zhang B., Li S., Wu J.,* and Shi* Y., Structural Basis of Plant Homeodomain Finger 6 (PHF6) Recognition by Retinoblastoma Binding Protein 4 (RBBP4) Component of the Nucleosome Remodeling and Deacetylase (NuRD) Complex. Journal of Biological Chemistry (2015) 290:6630-6638.

14) Wang C, Zhu Y, Bao H, Jiang Y, Xu C, Wu J*, Shi Y*.A novel RNA-binding mode of the YTH domain reveals the mechanism for recognition of determinant of selective removal by Mmi1., Nucleic Acids Res. 2015 Dec 15. pii: gkv1382. [Epub ahead of print]

联系方式：

Tel: 86-551-63607464

Fax:86-551-63601443

e-mail: yyshi@ustc.edu.cn

Homepage: http://bionmr.ustc.edu.cn