博士生导师

硕士生导师

教师姓名：陈焕春

教师英文名称：Chen Huanchun

教师拼音名称：Chen Huanchun

电子邮箱：chenhch@mail.edu.cn

所在单位：华中农业大学

职务：中国工程院院士

在职信息：在职

毕业院校：德国慕尼黑大学

个人简介

陈焕春，男，湖北恩施人。华中农业大学教授、博士生导师，生猪健康养殖协同创新中心主任。国务院政府特殊津贴、何梁何利基金科学与技术进步奖、中华农业英才奖、“十一五”国家科技计划执行突出贡献奖、湖北省科学技术突出贡献奖获得者。德国慕尼黑大学兽医学博士。现任中国兽医协会会长、华中农业大学农业微生物学国家重点实验室学术委员会主任、中国农业科学院哈尔滨兽医研究所兽医生物技术国家重点实验室学术委员会主任、教育部高等学校教学指导委员会动物生产类专业教学指导委员会主任委员（2013）、国务院突发事件应急专家委员会委员、科技部973传染病专家组副组长、863现代农业技术领域专家组副组长（2017）、农业部科技委专家委员会委员、教育部科技委专家委员会委员、农业部新兽药评审委员会委员、农业部转基因专项技术副总师等职。

主持国家自然科学基金、973（2006,2010）、863、国家支撑计划等重大科研课题50余项，研制出30余种基因工程疫苗和分子诊断试剂盒，获得了19个转基因安全证书、24个新兽药注册证书、49个发明专利、国家重点新产品证书5项，获得国家科技进步二等奖4项、湖北省科技进步一等奖6项、国家教学成果二等奖1项。在国内外期刊发表论文600余篇，SCI收录200余篇，出版专著3部，参编3部，已培养毕业博士95人，硕士112人。领导的研究团队入选国家自然科学基金委员会创新群体。

教育经历

1984.10—1989.01德国慕尼黑大学 攻读博士研究生

工作经历

1989.02—1993.09华中农业大学 讲师、副教授

1993.10—1994.10德国慕尼黑大学 合作科研

1994.11—2002.12华中农业大学 教授、博士生导师、畜牧兽医学院院长

2003.01—2007.12华中农业大学 教授、副校长、中国工程院院士

2008.01—至 今 华中农业大学 教授、中国工程院院士

研究领域

动物传染病学

科研成果

A著作类

1.《规模化猪场疫病控制及净化》主编

2.《兽医手册》主编

3.《伪狂犬病》主编

B论文类 （部分）

1.Ding Z, An K, Xie LL, Wu W, Zhang RX, Wang D, Fang Y, Chen HC, Xiao SB, Fang LR*. Transmissible gastroenteritis virus infection induces NF-kappa B activation through RLR-mediated signaling. Virology. 2017, 507: 170-178 3.354

2.He W, Zhao ZK, Anees A, Li YC, Ashraf U, Chen Z, Song YF, Chen HC, Cao SB, Ye J*. p21-Activated Kinase 4 Signaling Promotes Japanese Encephalitis Virus-Mediated Inflammationin Astrocytes. Frontiers In Cellular And Infection Microbiology. 2017, 7 4.3

3.Zheng Chengkun, Zhao Xigong, Zeng Ting, Cao Manman, Xu Jiali, Shi Guolin, Li Jinquan, Chen Huanchun, Bei Weicheng*. Identification of four type II toxin-antitoxin systems in Actinobacillus pleuropneumoniae. FEMS microbiology letters.2017, 7 1.7649

4.Sun X, Wang SY, Lin X , Zhao LZ, Zhang D, Yi CY, Sun XM, Chen HC, Jin ML*.Proteome analysis of Duck Tembusu virus (DTMUV)-infected BHK-21 cells.Proteomics.2017, 17:12 4.041

5.Xu Jiali, Zheng Chengkun, Cao Manman, Zeng Ting, Zhao Xigong, Shi Guolin, Chen Huanchun, Bei Weicheng*.The manganese efflux system MntE contributes to the virulence of Streptococcus suis serotype 2.Microbial pathogenesis.2017, 110:23-30 2.009

6.Wang X, Wu CX, Song XR, Chen HC, Liu ZF*. Comparison of pseudorabies virus China reference strain with emerging variants reveals independent virus evolution within specific geographic regions.Virology. 2017, (506): 92-98 3.354

7.Qian Suhong, Fan Wenchun, Liu Tingting, Wu Mengge, Zhang Huawei, Cui Xiaofang, Zhou Yun, Hu Junjie, Wei Shaozhong, Chen Huanchun, Li Xiangmin*, Qian Ping. Seneca Valley Virus suppresses host type I interferon production by targeting adaptor proteins MAVS TRIF and TANK for cleavage. Journal of virology.2017, 4 Journal of virology 3.354

8.Wang SY, Sun X, Yi CY, Zhang D, Lin X, Sun XM, Chen HC, Jin ML*. AGO2 Negatively Regulates Type I Interferon Signaling Pathway by Competition Binding IRF3 with CBP/p300.Frontiers In Cellular And Infection Microbiology.2017, 7 4.3

9.Rasheed MA, Qi JJ, Zhu XF, He CF, Menghwar H, Khan FA, Gang Z, Zubair M, Hu CM, Chen YY, Chen HC, Guo AZ*. Comparative Genomics of Mycoplasma bovis Strains Reveals That Decreased Virulence with Increasing Passages Might Correlate with Potential Virulence-Related Factors. Frontiers In Cellular And Infection Microbiology. 2017, 7 4.3

10.Wang Y, Li JT, Zhang AD, Zhu WF, Zhang Q, Xu ZM, Yan SX, Sun XM, Chen HC, Jin ML*. iTRAQ-based quantitative proteomic analysis reveals potential virulence factors of Erysipelothrix rhusiopathiae. Journal Of Proteomics.2017, 160: 28-37 3.914

11.Zou Z, Huang K, Wei YM, Chen HC, Liu ZD, Jin ML*. Construction of a highly efficient CRISPR/Cas9-mediated duck enteritis virus-based vaccine against H5N1 avian influenza virus and duck Tembusu virus infection. Scientific Reports.2017, 7 4.259

12.Peng Z, Liang W, Liu WJ, Chen HC, Wu B*.Genome characterization of Pasteurella multocida subspecies septica and comparison with Pasteurella multocida subspecies multocida and gallicida. Archives Of Microbiology.2017, 199(4): 635-640 1.6

13.Ye Jing, Chen Zheng, Li Yunchuan, Zhao Zikai, He Wen, Zohaib Ali, Song Yunfeng, Deng Chenglin, Zhang Bo, Chen Huanchun, Cao Shengbo*.Japanese Encephalitis Virus NS5 Inhibits Type I Interferon (IFN) Production by Blocking the Nuclear Translocation of IFN Regulatory Factor 3 and NF-kappaB. Journal of virology.2017, 91:8 3.354

14.Zhou YR, Fang LR, Wang D, Cai KM, Chen HC, Xiao SB*. Porcine Reproductive and Respiratory Syndrome Virus Infection Induces Stress Granule Formation Depending on Protein Kinase R-like Endoplasmic Reticulum Kinase (PERK) in MARC-145 Cells. Frontiers In Cellular And Infection Microbiology.2017, 7 4.3

15.Zhang Shishuo, Wang Ruifang, Su Huijuan, Wang Biaoxiong, Sizhu Suolang, Lei Zhixin, Jin Meilin, Chen Huanchun, Cao Jiyue, Zhou Hongbo*. Sus scrofa miR-204 and miR-4331 Negatively Regulate Swine H1N1/2009 Influenza A Virus Replication by Targeting Viral HA and NS Respectively. International journal of molecular sciences.2017, 18:4 3.226

16.Fan WC, Qian P, Wang DD, Zhi XW, Wei YM, Chen HC, Li XM*. Integrin alpha v beta 3 promotes infection by Japanese encephalitis virus. Research In Veterinary Science. 2017, 111: 67-74 1.298

17.Li YY, Zhou M, Luo ZC , Zhang YC, Cui M , Chen HC, Fu ZF, Zhao L*. Overexpression of Interleukin-7 Extends the Humoral Immune Response Induced by Rabies Vaccination. Journal Of Virology.2017, 91: 7 3.354

18.Ye J, Chen Z, Li YC, Zhao ZK, He W, Zohaib A, Song YF, Deng CL, Zhang B, Chen HC, Cao Shengbo. Japanese Encephalitis Virus NS5 Inhibits Type I Interferon (IFN) Production by Blocking the Nuclear Translocation of IFN Regulatory Factor 3 and NF-kappa B. Journal Of Virology.2017, 91: 8 3.354

19.Liu XK, Yang C, Hu Y, Lei EM, Lin X, Zhao LZ, Zou Z, Zhang AD, Zhou HB, Chen HC, Qian P*, Jin ML*. HIST1H1C Regulates Interferon-beta and Inhibits Influenza Virus Replication by Interacting with IRF3.Frontiers In Immunology. 2017, 8 6.43

20.Li P, Wang R, Dong WQ, Hu LL, Zong BB, Zhang YY, Wang XG, Guo AZ, Zhang AD, Xiang YZ, Chen HC, Tan C*.Comparative Proteomics Analysis of Human Macrophages Infected with Virulent Mycobacterium bovis. Frontiers In Cellular And Infection Microbiology.2017, 7, DOI: 10.3389/fcimb.2017.00065 4.3

21.Yuan FY, Tan C , Liu ZW, Yang K, Zhou D, Liu W, Duan ZY, Guo R, Chen HC, Tian YX* , Bei WC*. The 1910HK/RR two-component system is essential for the virulence of Streptococcus suis serotype 2. Microbial Pathogenesis.2017, 104: 137-145 2.009

22.Sun YX, Deng ML, Peng Z, Hu RM, Chen HC, Wu B*. Genetic and phylogenetic analysis of feline calicivirus isolates in China. Veterinary Journal. 2017, 220: 24-27 1.802

23.Jing HY, Fang LR, Ding Z, Wang D, Hao WQ, Gao L, Ke WT, Chen HC, Xiao SB*. Porcine Reproductive and Respiratory Syndrome Virus nsp1 alpha Inhibits NF-kappa B Activation by Targeting the Linear Ubiquitin Chain Assembly Complex. Journal Of Virology.2017, 91: 3 3.354

24.Wang Z, Li MM, Zhou M, Zhang YJ , Yang J, Cao YD, Wang KL, Cui M, Chen HC, Fu ZF, Zhao L*. A Novel Rabies Vaccine Expressing CXCL13 Enhances Humoral Immunity by Recruiting both T Follicular Helper and Germinal Center B Cells. Journal Of Virology.2017, 91: 3 3.354

25.Fan WC, Liu TT, Li XM, Zhou Y, Wu MG, Cui XF, Chen HC, Qian P*. TRIM52: A nuclear TRIM protein that positively regulates the nuclear factor-kappa B signaling pathway. Molecular Immunology. 2017, 82: 114-122 3.236

26.Jing Huiyuan, Fang Liurong, Ding Zhen, Wang Dang, Hao Wenqi, Gao Li, Ke Wenting, Chen Huanchun, Xiao Shaobo. Porcine Reproductive and Respiratory Syndrome Virus nsp1alpha Inhibits NF-kappaB Activation by Targeting the Linear Ubiquitin Chain Assembly Complex. Journal of virology.2017, 91:3 3.354

27.Li YT, Ming F, Huang HM, Guo KL , Chen HC, Jin ML, Zhou HB*. Proteome Response of Chicken Embryo Fibroblast Cells to Recombinant H5N1 Avian Influenza Viruses with Different Neuraminidase Stalk Lengths. Scientific Reports.2017, 7 4.259

28.Liu F, Fu JY, Liu CY, Chen J, Sun MH, Chen HC, Tan C*, Wang XR*. Characterization and distinction of two flagellar systems in extraintestinal pathogenic Escherichia coli PCN033. Microbiological.Research.2017, 196: 69-79 3.037

29.Zheng CK, Ren SJ, Xu JL, Zhao XG, Shi GL, Wu JP, Li JQ, Chen HC, Bei WC*. Contribution of NADH oxidase to oxidative stress tolerance and virulence of Streptococcus suis serotype. Virulence.2017, 8(1): 53-65 4.665

30.Chen YY, Wang JR, Ge P, Cao DJ, Miao BP, Robertson I, Zhou X, Zhang L, Chen HC, Guo AZ*. Tissue inhibitor of metalloproteinases 1 a novel biomarker of tuberculosis. Molecular Medicine Reports. 2017, 15(1): 483-487 1.692

31.Farhan, Chen Yingyu, Hu Changmin, Chen Huanchun, Guo Aizhen*. Mycoplasma bovis NADH oxidase functions as both a NADH oxidizing and O2 reducing enzyme and an adhesin. Scientific reports. 2017, 7(1):44 4.2589

32.Peng Z, Liang W, Wang YG, Liu WJ, Zhang HF, Yu T, Zhang AD, Chen HC, Wu B*. Experimental pathogenicity and complete genome characterization of a pig origin Pasteurella multocida serogroup F isolate HN07. Veterinary Microbiology.2017, 198: 23-33 2.628

科研项目

1.国家自然科学基金创新群体，动物重要病原分子生物学与致病机理，2015-2017

2.农业部公益性行业专项，副猪嗜血杆菌病和猪传染性胸膜肺炎防治技术研究与示范，2013-2017

3.现代农业产业技术体系，“十三五”新增岗位科学家，2017-2020

主要奖励

1.2001年12月10日，国家科学技术进步二等奖，伪狂病鄂A株分离鉴定及分子生物学与综合防治研究

2.2005年9月1日，国家级教学成果奖，动物医学专业人才培养方案的改革与实践

3.2007年12月1日，湖北省科学技进步一等奖，禽流感快速检测技术研究

4.2008年12月1日，湖北省科学技进步一等奖，猪细小病毒病诊断技术、新型疫苗及综合防制措施研究

5.2007年2月11日，国家科学技术进步二等奖，瘦肉型猪品种（系）及配套技术的创新研究与开发

6.2011年12月23日，国家科学技术进步二等奖，动物流感系列快速检测技术的建立及应用

6.2013年12月1日，湖北省科学技进步一等奖，猪链球菌病防控关键技术研究与应用

7.2014年12月1日，湖北省科技进步一等奖，猪传染性胸膜肺炎防控关键技术研究与应用

8.2015年12月1日，湖北省科技进步一等奖，猪流感病毒致病机制与防控技术

9.2016年12月1日，湖北省科技进步一等奖，猪乙型脑炎防控关键技术研究与应用

10.2016年12月1日，国家科学技术进步二等奖，我国重大猪病防控技术集成与应用