男 |汉| 博士 |教授

联系电话18266188287

教育及工作经历

◆ 2011年6月- 今：德州学院，讲师，副教授，教授；生物大数据分析；

◆2019年3月-2020年8月：美国伊利诺伊大学芝加哥校区，访问学者，计算生物物理；

◆ 2009年2月- 2011年4月：美国德克萨斯大学圣安东尼奥校区，访问学者，计算生物物理；

◆ 2006年9月- 2011年6月：山东师范大学，原子分子物理，计算生物物理方向，硕博连读；

个人总结

本人性格沉稳，爱岗敬业，有较强的组织性，纪律性。科研工作主要是通过计算的方法对生物大数据进行分析，采用分子动力学模拟结合多种计算方法处理生物大数据，发现药物分子作用机制并进行改进，设计新的药物分子，并研究药物分子的动力学特征，熟练使用python程序进行编程。乐于开展新的研究领域，发表SCI论文30多篇（其中一作或通信作者20篇）。主持并完成了国家自然科学基金1项，山东省自然科学基金2项。德州市有突出贡献的中青年专家，学校的学术带头人，电子信息工程重点学科负责人，德州学院天衢英才。

发表的SCI论文

一作文章

[1]. Guodong Hu; Huan-Xiang Zhou, Binding free energy decomposition and multiple unbinding paths of buried ligands in a PreQ1 riboswitch.PLoS Comput Biol,2021, 17 (11), e1009603.

[2]. Tongchuan Zhang;Guodong Hu; Yuedong Yang; Jihua Wang; Yaoqi Zhou, All-Atom Knowledge-Based Potential for RNA Structure Discrimination Based on the Distance-Scaled Finite Ideal-Gas Reference State.J Comput Biol,2020, 27 (6), 856-867.

[3]. Guodong Hu; Haiyan Li; Shicai Xu; Jihua Wang, Ligand Binding Mechanism and Its Relationship with Conformational Changes in Adenine Riboswitch.Int J Mol Sci,2020, 211926.

[4]. Guodong Hu; Xiu Yu; Yunqiang Bian; Zanxia Cao; Shicai Xu; Liling Zhao; Baohua Ji; Wei Wang; Jihua Wang, Atomistic Analysis of ToxN and ToxI Complex Unbinding Mechanism.Int J Mol Sci,2018, 19 (11), 3523.

[5]. Guodong Hu; Aaijing Ma; Jihua Wang, Ligand Selectivity Mechanism and Conformational Changes in Guanine Riboswitch by Molecular Dynamics Simulations and Free Energy Calculations.J Chem Inf Model,2017, 57 (4), 918–928.

[6]. Guodong Hu; Aijing Ma; Xianghua Dou; Liling Zhao; Jihua Wang, Computational Studies of a Mechanism for Binding and Drug Resistance in the Wild Type and Four Mutations of HIV-1 Protease with a GRL-0519 Inhibitor.Int J Mol Sci,2016, 17 (6), 819.

[7]. Guodong Hu; Shicai Xu; Jihua Wang, Characterizing the Free-Energy Landscape of MDM2 Protein-Ligand Interactions by Steered Molecular Dynamics Simulations.Chem Biol Drug Des,2015, 86 (6), 1351-1359.

[8]. Guodong Hu; Zanxia Cao; Shicai Xu; Wei Wang; Jihua Wang, Revealing the binding modes and the unbinding of 14-3-3sigma proteins and inhibitors by computational methods.Sci Rep,2015, 5, 16481.

[9]. Guodong Hu; Jihua Wang, Ligand selectivity of estrogen receptors by a molecular dynamics study.Eur J Med Chem,2014, 74, 726-735.

[10]. Guodong Hu; Haiyan Li; Jing-Yuan Liu; Jihua Wang, Insight into Conformational Change for 14-3-3σ Protein by Molecular Dynamics Simulation. Int J Mol Sci,2014, 15 (2), 2794-2810.

[11]. Guodong Hu; Lisheng Qi; Xianghua Dou; Jihua Wang, The influences of protonation state of histidine on aromatic/arginine region of aquaporin-1 protein.Mol Simulat,2013, 39 (4), 261-269.

[12]. Guodong Hu; L. Y. Chen; Jihua Wang, Insights into the mechanisms of the selectivity filter of Escherichia coli aquaporin Z.J Mol Model,2012, 18 (8), 3731-3741.

[13]. Guodong Hu; Qinggang Zhang; L. Y. Chen, Insights into scFv:drug binding using the molecular dynamics simulation and free energy calculation.J Mol Model,2011, 17 (8), 1919-1926.

[14]. Guodong Hu; Tong Zhu; Shao-Long Zhang; Dunyou Wang; Qinggang Zhang, Some insights into mechanism for binding and drug resistance of wild type and I50V V82A and I84V mutations in HIV-1 protease with GRL-98065 inhibitor from molecular dynamic simulations.Eur J Med Chem,2010, 45 (1), 227-235.

[15]. Guodong Hu; Dunyou Wang; Xinguo Liu; Qinggang Zhang, A computational analysis of the binding model of MDM2 with inhibitors.J Comput Aided Mol Des,2010, 24 (8), 687-697.

[16]. Guodong Hu; L. Y. Chen, In silico experiments of single-chain antibody fragment against drugs of abuse.Biophys Chem,2010, 153 (1), 97-103.

[17]. Guodong Hu; Jianzhong Chen; Shuhua Shi; Changhong Yi; Shao-Long Zhang; Qinggang Zhang, Molecular dynamics study of the effects of V82A and L90M on PR-IDV complex.Acta Chimica Sinica,2010, 68 (7), 603-610.

[18]. Guodong Hu; Shao-Long Zhang; Qinggang Zhang, Molecular iynamics simulations and free energy calculation of FKBP12 protein and its inhibitors.Acta Chimica Sinica,2009, 67 (9), 1019-1025.

通信非一作文章

[19]. Meng Tian; Zhenhua Li; Ruihong Song; Yingxian Li; Chengang Guo; Yujie Sha; Wanling Cui; Shicai Xu;Guodong Hu; Jihua Wang, Graphene biosensor as affinity biosensors for biorecognition between Guanine riboswitch and ligand.Applied Surface Science,2020, 503, 144303.

[20]. 李高峰;扈国栋;张晨;季保华;王吉华,计算方法研究HIV-1蛋白酶及其变异与小分子GRL-0519的相互作用.生物化学与生物物理进展,2017, 44 (9), 783-791.

[21]. Qianjun Liu;Guodong Hu; Zanxia. Cao; Jihua. Wang; Haifeng Chen, Conformational stability of PCID2 upon DSS1 binding with molecular dynamics simulation.J Mol Model,2015, 21 (5), 2664.

[22]. Shuhua Shi;Guodong Hu; Xiumie Zhang; Jihua Wang, A study of the interaction between HIV-1 protease and C 2-symmetric inhibitors by computational methods.J Mol Model,2014, 20 (8), 2369.

参与文章

[23]. Bailing Zhou; Baohua Ji; Kui Liu;Guodong Hu; Fei Wang; Qingshuai Chen; Ru Yu; Pingping Huang; Jing Ren; Chengang Guo; Huiying Zhao; Hongmei Zhang; Dongbo Zhao; Zhiwei Li; Qiangcheng Zeng; Jiafeng Yu; Yunqiang Bian; Zanxia Cao; Shicai Xu; Yuedong Yang; Yaoqi Zhou; Jihua Wang, EVLncRNAs 2.0: an updated database of manually curated functional long non-coding RNAs validated by low-throughput experiments.Nucleic Acids Research,2021, 49 (D1), D86-D91.

[24]. Shicai Xu; Chao Zhang; Shouzhen Jiang;Guodong Hu; Xiaoyue Li; Yan Zou; Hanping Liu; Jun Li; Zhenhua Li; Xiaoxin Wang; Mingzhen Li; Jihua Wang, Graphene foam field-effect transistor for ultra-sensitive label-free detection of ATP.Sensors and Actuators B: Chemical,2019, 284, 125-133.

[25]. B. Zhou; H. Zhao; J. Yu; C. Guo; X. Dou; F. Song; G. Hu; Z. Cao; Y. Qu; Y. Yang; Y. Zhou; J. Wang, EVLncRNAs: a manually curated database for long non-coding RNAs validated by low-throughput experiments.Nucleic Acids Res,2018, 46 (D1), D100-D105.

[26]. Jihua Wang; Jiafeng Yu; Liling Zhao;Guodong Hu; Zanxia Cao, Deepening constantly understanding of protein folding problem.J Biomol Struct Dyn,2013, 31 (9), 956-960.

[27]. Tong Zhu;Guodong Hu; Qinggang Zhang, Quasi-classical trajectory study of the reaction O(P-3) plus HCl -> OH + Cl and O(P-3) plus DCl -> OD plus Cl: Vector and scalar properties.J Mol Struc-Theochem,2010, 948 (1-3), 36-42.

[28]. Tong Zhu;Guodong Hu; Qinggang Zhang, Quasi-classical trajectory study of reaction O (P-3) plus HCl (v=2; j=1, 6, 9) -> OH plus Cl.Chinese Phys Lett,2010, 27 (3), 033102-033104.

[29]. Tong Zhu;Guodong Hu; Jianzhong Chen; Xinguo Liu; Qinggang Zhang, Theoretical study of stereodynamics for reaction O(P-3)+HCl.Chinese Phys B2010, 19 (8), 083402-083406.

[30]. Changhong Yi; Jianzhong Chen;Guodong Hu; Qinggang Zhang, A computational analysis of pyrazole-based inhibitors binding to Hsp90 using molecular dynamics simulation and the MM-GBSA method.Mol Simulat,2010, 36 (6), 454-460.

[31]. Shuhua Shi;Guodong Hu; Jianzhong Chen; Shao-Long Zhang; Qinggang Zhang, Molecular dynamics simulations on the role of protonation states in HIV-1 protease-indinavir complex.Acta Chimica Sinica,2009, 67 (24), 2791-2797.

[32]. Shuhua Shi; Jianzhong Chen;Guodong Hu; Changhong Yi; Shao-Long Zhang; Qinggang Zhang, Molecular insight into the interaction mechanisms of inhibitors BEC and BEG with HIV-1 protease by using MM-PBSA method and molecular dynamics simulation.J Mol Struc-Theochem,2009, 913 (1-3), 22-27.

[33]. Jianzhong Chen; Maoyou Yang;Guodong Hu; Shuhua Shi; Changhong Yi; Qinggang Zhang, Insights into the functional role of protonation states in the HIV-1 protease-BEA369 complex: molecular dynamics simulations and free energy calculations.J Mol Model,2009, 15 (10), 1245-1252.